Purine nucleotides
Research Products International Corp ATP 100 G
An essential nucleotide triphosphate with a variety of roles in energy metabolism, signal transduction and nucleic acid metabolism.
Cambridge Isotope Laboratories Adenosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 50 mg
Adenosine phosphoramidite (U-13C10 98% U-15N5 98%) CP 95% 50 mg
Cayman Chemical GunosIn 5-monphosphates 5g
A nucleotide that upon phosphorylation to GTP becomes incorporated into RNA; used to study modulation of glutamatergic neurotransmission
Apexbio Technology LLC 8-Azido-ATP(Synonyms: 8-Azidoadenosine 5'-triphosphate, 8-N3-ATP, 8-Azido-ATP, 8-Azidoadenosine triphosphate), 10ul (100 mM).
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Medchemexpress LLC Adenosine 5'-monophosphate | 61-19-8 | MFCD00149360 | 99.8% | 347.22 | C10H14N5O7P | 10 MG
Adenosine 5'-monophosphate (AMP) is a nucleotide involved in cellular energy transfer and signal transduction. This research-grade biochemical is supplied as a solid or solution and is intended for in vitro research applications; the manufacturer lists high purity and molecular weight of 347.22 g/mol.
- High purity (99.8%) suitable for research use
- Defined molecular weight of 347.22 g/mol
- Available as solid and as DMSO solution for flexible use
- Commonly used in biochemical assays and receptor pharmacology studies
- Provided with supporting documentation such as datasheets and COA when available
Medchemexpress LLC Adenosine-15N5 | 168566-57-2 | 99.9% | 272.21 | C10H13(15N)5O4 | 10 MG
Adenosine-15N5 is an isotopically labeled adenosine in which five nitrogen atoms are 15N. It is supplied as a 10 mg solid intended for use as an internal standard, tracer, or reference in mass spectrometry, metabolic studies, and biochemical assays. The material is provided with supporting documentation and handling guidance.
- Isotopically labeled with five 15N atoms.
- High purity (99.9%).
- Molecular weight 272.21 g/mol.
- Supplied as a 10 mg solid vial.
- Soluble in DMSO (33.33 mg/mL); ultrasonic and warming recommended.
- Includes COA, SDS, and handling instructions.
- Suitable as an internal standard or tracer for analytical applications.
Medchemexpress LLC Adenosine receptor antagonist 2 | 2703054-47-9 | 99.4% | 444.5 g/mol | C23H21FN8O | 5 MG
Adenosine receptor antagonist 2 is an orally active small-molecule antagonist of A2a and A2b adenosine receptors (CAS 2703054-47-9) with potent in vitro activity and demonstrated antitumor efficacy in preclinical mouse models. It is provided for research use and characterized with reported pharmacokinetic data and high purity.
- Potent A2a and A2b inhibition: IC50 = 1 nM and 3 nM.
- Demonstrated antitumor activity in mouse models.
- Characterized pharmacokinetics in vivo for oral and intravenous dosing.
- High purity suitable for preclinical studies.
- Available in small research package sizes for dosing flexibility.
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mg
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research