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Two-carbon nitrogen ring bases (adenine and guanine) covalently linked to a sugar (ribose or deoxyribose) and one to three phosphate groups; can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
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7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate. Its phosphorothioate analog is a potent cap-dependent translation inhibitor.
Potent cap-dependent translation inhibitor.
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Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
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7-Methylguanosine 5'-diphosphate sodium (m7GDP sodium) is a nucleotide cap analog used in RNA and mRNA research. Supplied as a solid sodium salt with high purity, it serves as a reagent or standard in studies of mRNA capping, cap-binding proteins, and enzymatic assays involving guanine nucleotides.
Used as a cap analog in mRNA cap-analogue synthesis and biochemical assays.
Supplied as a solid sodium salt suitable for laboratory use.
High purity (97.1%) for consistent experimental performance.
Available in small research pack sizes for low-quantity applications.
Store sealed at -20°C; in solution, store at -80°C for longer-term stability.
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Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor. purity: 98%
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3AE-phosphoadenosine 5AE-phosphate (PAP) a 3AE-phosphorylated nucleotide is found in almost all organisms and is obtained as a by-product of sulfur and lipid metabolism.
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